You have heard of Ozempic, Wegovy and Mounjaro. You know they help people lose weight. But how do they actually work inside your body? Here is a clear, jargon-free explanation.
The GLP-1 System
GLP-1 stands for glucagon-like peptide-1. It is a hormone your body naturally produces in your gut after eating. Its job is to tell your brain you are full, slow down digestion and help regulate blood sugar.
In people who struggle with weight, this system often does not work as effectively as it should. GLP-1 medications boost this natural signal, making it much stronger and longer-lasting.
What Mounjaro Does Differently
Mounjaro (tirzepatide) is a dual-action medication. It activates both the GLP-1 and GIP receptors. This double action is why clinical trials show Mounjaro achieving up to 23% body weight loss, making it the most effective weight loss medication currently available.
What Wegovy Does
Wegovy (semaglutide) activates the GLP-1 receptor only. It has been proven to achieve around 15% body weight loss in clinical trials and has strong cardiovascular benefits backed by the SELECT trial.
What You Actually Feel
Most patients report a significant reduction in appetite and food noise (the constant thinking about food). Many describe it as feeling naturally satisfied with smaller portions, rather than fighting willpower against hunger.
Side effects are usually mild and temporary: nausea in the first few weeks, which typically resolves as your body adjusts to each dose.
The Dose Escalation
Both medications start at a low dose and increase gradually over several months. This approach minimises side effects and allows your body to adjust. Your clinician monitors your progress and adjusts your dose based on your response.
Is It Right for You?
GLP-1 medications are prescribed for adults with a BMI of 30+ (or 27+ with weight-related health conditions). They are not cosmetic treatments. They are clinically proven medicines for people whose weight is affecting their health.